Gonadal hormones influence core body temperature during calorie restriction

Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every mi...

Calorie Restriction, Longevity and Cognitive Function

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...

Molecules affecting hypothalamic control of core body temperature in response to calorie intake

Core body temperature (CBT) and calorie intake are main components of energy homeostasis and two important regulators of health, longevity, and aging. In homeotherms, CBT can be influenced by calorie intake as food deprivation or calorie restriction (CR) lowers CBT whereas feeding has hyperthermic effects. The finding that in mice CBT prolonged lifespan independently of CR, suggested that the m...

Calorie restriction accelerates the catabolism of lean body mass

Background: Muscle inactivity and low energy intake commonly occur in persons with acute or chronic disease, in astronauts during space flight, and during aging. Objective: We used a crossover design to investigate the effects of the interactions of inactivity and calorie restriction on whole-body composition and protein kinetic regulation in 9 healthy volunteers. Design: Lean body mass (LBM) w...